Surgical Pathology Criteria

Acinar Cell Cystadenoma of the Pancreas

Differential Diagnosis

Acinar Cell Cystadenoma of the Pancreas Mucinous Cystic Lesions Serous Cystic Lesions
Lined at least in some areas by cells with granular eosinophilic apical cytoplasm Mucin positive but lacks granular cytoplasm Clear cytoplasm, PASd negative

Acinar Cell Cystadenoma of the Pancreas Acinar Cell Cystadenocarcinoma of the Pancreas
Cytologically bland Cytologically moderately atypical with prominent nucleoli
Mitotic figures absent to very rare Mitotic figures frequent
No infiltration Frequently infiltrative
Both are very rare

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