Acinar Cell Carcinoma of the Pancreas
Supplemental Studies
Immunohistology
| Keratin, CK7, CK19 | 70-100% |
| Trypsin | 95% |
| Chymotrypsin | pos |
| bcl10 | 86% |
| PDX1 | 91% |
| Lipase | freq neg |
| AFP | variable |
| Amylase | infrequent |
- Synaptophysin and chromogranin may stain scattered cells
- If >25% positive, diagnose as mixed acinar-endocrine carcinoma
Laboratory studies
- Serum lipase may be markedly elevated
- AFP may be elevated
