Surgical Pathology Criteria

Myeloproliferative Neoplasms

Definition

Historical Name

Diagnostic Criteria

Disease Tyrosine Kinase Affected Peripheral Blood Marrow Cell Lines Affected Marrow Fibrosis
CML ABL Leukocytosis with increased basophils & Igs Markedly increased myeloids Variable
Polycythemia Vera JAK2 Normo- or hypochromic anemia, may have increased platelets & basophils Panmyelosis, variable erythroid hyperplasia, atypical megakaryocytes Increased in spent phase
Essential Thrombocythemia JAK2 or MPL Platelets increased, frequently abnormal Markedly increased megakaryocytes Minimal
Primary Myelofibrosis JAK2 or MPL Leukoerythroblastic, teardrop RBCs Panmyelosis, atypical megakaryocytes Increased in fibrotic phase
Chronic Neutrophilic Leukemia JAK2 rare Increased, normal granulocytes Granulocytic hyperplasia None
Chronic Eosinophilic Leukemia, NOS None Eosinophilia Eosinophilic hyperplasia with maturation Occasional
Hematolymphoid Neoplasms with Eosinophilia & Specific Tyrosine Kinase Abnormalities PDGFRA, PDGFRB, FGFR1 Eosinophilia Eosinophilic hyperplasia with maturation May be increased
Mastocytosis KIT Variable Variable Frequent
Myeloproliferative Neoplasm, Unclassifiable None Variable Variable Variable


Dita Gratzinger MD PhD
Tracy I George MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342

Original posting: 10/23/11

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