Surgical Pathology Criteria

Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB or FGFR1

Differential Diagnosis


  Idiopathic Hypereosinophilia Idiopathic Hypereosinophilic Syndrome Chronic Eosinophilic Leukemia NOS Hematolymphoid Neoplasms with Specific Genetic Abnormalities#
Hypereosinophilia Yes Yes Yes Yes
Tissue Damage No Yes Subset Subset
Clonality** No Not demonstrated Yes Yes
Blasts ≥20% No No No Subset
Abnormalities of BCR-ABL1, PDGFRA, PDGFRB, KIT, FGFR1 or CBFB No No No Yes

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