Myeloid and Lymphoid Neoplasms with Eosinophilia and Abnormalities of PDGFRA, PDGFRB or FGFR1
Clinical
- Neoplasms involving PDGFRA
- Male:female 17:1
- Wide age range, peaks at middle age
- Tissue damage from infiltrates
- Cardiac failure due to endomyocardial fibrosis is most significant
- Sensitive to imatinib
- Neoplasms involving PDGFRB
- Male:female 2:1
- Wide age range, peaks at middle age
- Tissue damage from infiltrates
- Cardiac failure due to endomyocardial fibrosis is most significant
- Sensitive to imatinib
- Neoplasms involving FGFR1
- Male:female 1.5:1
- Wide age range, peaks around 30 years
- May present as lymphoma or as myeloproliferative neoplasm
- Not sensitive to imatinib
- Chronic myelomonocytic leukemia with eosinophilia
- t(5:12) involving PDGFR on conventional cytogenetics
- Imatinib sensitive
- Chronic eosinophilic leukemia with FIP1
