Surgical Pathology Criteria

Chronic Myelomonocytic Leukemia (CMML)

Differential Diagnosis

  CML-CP CMML-1 Myeloid Neoplasm with PDGFRB
Ph Chromosome and/or BCR-ABL1 Translocation Almost 100% Absent Absent

WBC

Left shifted neutrophilia* Monocytosis, may have left shifted neutrophilia Variable, may have left shifted neutrophilia, monocytosis, eosinophilia
Blood eosinophils Often increased Not increased Variable
Blood basophils Increased Not increased Variable
Blood monocytes Variable,** <1x103/μL Always >1x103/μL often <1x103/μL
Blood immature granulocytes >20% Usually <10% often <10%
Blood blasts Usually <2% <5% Variable
Granulocytic dysplasia Absent +/- Variable
*rare p230 BCR-ABL1 isoform may show mature neutrophilia, **rare p190 BCR-ABL1 isoform associated with monocytosis

Non-neoplastic Monocytosis

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