Chronic Myelogenous Leukemia (CML)
Clinical
- Median age 60-65
- Broad range 20-80 years
- Rare in children
- Onset frequently insidious
- Headaches, weakness, weight loss, pruritis
- Hemorrhage, thrombosis, hyperviscosity symptoms
- Splenomegaly
- CML is the prototype tyrosine kinase inhibitor (e.g. imatinib) responsive malignancy
