Surgical Pathology Criteria

Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative

Supplemental Studies

Special stains

Genetic studies

 

Disorder Molecular or Cytogenetic Alteration Test Used
Chronic myelogenous leukemia BCR-ABL1 CG, FISH, PCR on PB or BM
Hematolymphoid neoplasms with eosinophilia and PDGFR/FGFR abnormalities

FIP1L1-PDGFRA (usually CEL)

ETV6-PDGFRB (usually CMML with eosinophilia)

FGFR1 (various)

PDGFRa/b (various)

CG, FISH
Chronic eosinophilic leukemia NOS none specific, may have clonal CG abnormalities CG
Mastocytosis KIT D816V CG, PCR on BM, not PB
Acute myelogenous leukemia, even if <20% blasts inv or t(16)(p13.1q22); CBFB-MYH11 or t(8;21)(q22;q22) RUNX1-RUNX1T1 CG, FISH
PCR = polymerase chain reaction, PB = peripheral blood, CG = conventional cytogenetics, FISH = fluorescent in situ hybridization, BM = bone marrow, CEL = chronic eosinophilic leukemia, CMML = chronic myelomonocytic leukemia

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