Surgical Pathology Criteria

Nonspecific Interstitial Pneumonia

Differential Diagnosis

NSIP is a diagnosis of exclusion

Infection must be ruled out in every case

Usual Interstitial Pneumonia Nonspecific Interstitial Pneumonia
Temporal and spatial heterogeneity Temporal and spatial uniformity
Honeycomb change prominent Honeycomb change rare
Scant interstitial inflammation Prominent interstitial inflammation
Prominent fibroblastic foci Fibroblastic foci few, focal

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