Surgical Pathology Criteria

Nodular Lymphoid Hyperplasia

Differential Diagnosis

Nodular Lymphoid Hyperplasia Extranodal Marginal Zone B Cell Lymphoma
Predominantly germinal centers Monomorphous infiltrate, but germinal centers may be present
Involvement of pleura and cartilage rare Pleura and cartilage may be involved
Polyclonal Monoclonal


Follicular Bronchiolitis Nodular Lymphoid Hyperplasia
Scattered follicles around bronchioles Numerous germinal centers form mass lesion or lesions


Lymphocytic Interstitial Pneumonitis Nodular Lymphoid Hyperplasia
Diffuse involvement of alveolar septa Discrete nodule(s)
Germinal centers, if present, are a minor component Prominent germinal center hyperplasia


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