CK7 and other keratins negative to weak, CD10 pos, Racemase/AMACR pos
CK7 strong pos, CD10 neg, Racemase/AMACR neg
Variable expression of melanocytic markers
Melanocytic markers neg
CA9 basolateral positive
Grading / Staging
Although this grading system has not been validated as an indicator of prognosis for other types of renal cell neoplasia (due primarily to small numbers of reported cases) the system can be used to describe the morphologic features of these tumors
Grade should be assigned based on the siingle high power field showing the greatest degre of nuclear pleomorphism
Most cases grade 3
WHO/ISUP grading system for clear cell and papillary renal cell carcinomas
Nucleoli are absent or inconspicuous and basophilic at 400x magnification
Nucleoli are conspicuous and eosinophilic at 400x and visible but not prominent at 100x
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