Renal Medullary Carcinoma
Differential Diagnosis
| Urothelial Carcinoma |
Medullary Carcinoma of the Kidney |
| Adjacent usual urothelial carcinoma or carcinoma in situ frequently present |
Lacks urothelial components |
| Mean age >50 |
Mean age 20 |
| No association with sickle cell |
Associated with sickle cell trait |
| OCT3/4 negative |
OCT3/4 69% positive |
| Medullary Carcinoma of the Kidney |
Collecting Duct Carcinoma |
| Frequent solid and/or reticular areas |
Predominantly tubular and papillary |
| Mean age 20-24 |
Mean age 50-55 |
| Associated with sickle cell trait/disease |
No association with sickle cell |
| INI negative |
INI positive in 85% |
| OCT3/4 69% positive |
OCT3/4 negative |
The distinction may be largely clinical as there is considerable morphologic overlap
