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Surgical Pathology Criteria

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Oncocytic Papillary Renal Cell Carcinoma


  • Carcinoma of the kidney exhibiting papillary architecture with oncocytic lining cells

Diagnostic Criteria

  • Note: it is not presently clear if oncocytic papillary renal cell carcinoma is an independent type of carcinoma or if it represents a subtype of papillary renal cell carcinoma (PRCC)
    • Limited data available on behavior
      • Clearly differs from oncocytoma as some cases metastasize
      • May be less aggressive than type 2 PRCC
    • About half of reported cases share genetic abnormalities of PRCC
    • Immunophenotype reports are variable but generally are similar to PRCC
  • Predominantly papillary architecture in most cases
    • Thin fibrovascular cores
    • Rare cases are predominantly solid
      • Recognized based on other features below
    • (Note that rare oncocytomas may have focal papillary features, see Differential Diagnosis at left)
  • Lined by a single layer of oncocytic cells
    • Cuboidal to columnar cells
    • Abundant granular eosinophilic cytoplasm
    • Nuclei generally round and uniform
      • Most are Fuhrman grade 1 or 2
    • Nuclei frequently apical
  • Occasional features
    • Clusters of foamy macrophages
    • Tumor cell necrosis
    • Psammoma bodies
  • Racemase/AMACR/P504s positive

John P Higgins MD
Robert V Rouse MD
Department of Pathology
Stanford University School of Medicine
Stanford CA 94305-5342

Original posting:: January 24, 2011

Supplemental studies


  • The only consistent immunohistologic finding appears to be racemase positivity
  • The remainder of the results are highly variable from report to report including
    • CK7, cKIT (CD117), EMA, CD10, RCC membrane antigen, vimentin

Genetic studies

  • About half of reported series find abnormalities consistent with papillary renal cell carcinoma
    • Trisomy 7 and 17
    • Loss of Y chromosome
    • Some reports, however, do not find these abnormalities


Differential Diagnosis

Renal Oncocytoma Oncocytic Papillary Renal Cell Carcinoma
Solid, with minimal, poorly developed papillary change Usually predominantly papillary
At most, rare, focal foamy macrophages May have clusters of foamy macrophages
Necrosis is rare and only microscopic foci May have tumor cell necrosis
AMACR/racemase/P504S usually negative AMACR/racemase/P504S positive
Occasional oncocytic papillary renal cell carcinomas may be largely solid; the bottom three criteria are more important in such cases

Type 2 Papillary Renal Cell Carcinoma Oncocytic Papillary Renal Cell Carcinoma
Nuclei usually pseudostratified Nuclei usually linear, frequently apical
Cytoplasm eosinophilic but not abundant and granular Abundant granular eosinophilic cytoplasm
The distinction might be significant since oncocytic papillary carcinomas may have a better prognosis, but more data is needed.

Grading / Staging


  • Use Fuhrman criteria but clinical correlation is not clear (see below)


  • Use TNM for renal cell carcinoma

  • WHO/ISUP grading system for clear cell and papillary renal cell carcinomas
  • Grade 1 Nucleoli are absent or inconspicuous and basophilic at 400x magnification
    Grade 2 Nucleoli are conspicuous and eosinophilic at 400x and visible but not prominent at 100x
    Grade 3 Nucleoli are conspicuous and eosinophilic at 100x
    Grade 4 Extreme nuclear pleomorphism, multinucleate giant cells, and/or rhabdoid and/or sarcomatoid differentiation
  • Sarcomatoid differentiation may be seen in many types of renal carcinomas (de Peralta-Venturina; Cheville)
    • It no longer refers to a type of carcinoma
    • It is considered an adverse prognostic factor
      • Prognosis may be worse than simple grade 4 carcinoma
    • Defined as a spindle cell component measuring at least one low power (40x) field with either
      • Adjacent carcinoma, or
      • Evidence of epithelial differentiation in the spindle cells
    • Spindle cells usually show moderate to marked atypia
      • Frequent patterns include fibrosarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma
      • Occasional cases have low grade atypia in spindle component
      • No clinical significance to type of differentation or degree of atypia
    • May arise in setting of many types of carcinoma
      • Clear cell RCC (reported 5-8% incidence of sarcomatoid foci, in our experience it is less frequent)
      • Papillary RCC (2-3% incidence)
      • Chromophobe RCC (9% incidence)
      • Collecting duct carcinoma (39% incidence)


  • Mean age about 65
    • Only seen in adults, range 40-81
  • M:F = 9:1
  • Limited data available on behavior
    • Clearly differs from oncocytoma as some cases metastasize
    • May be less aggressive than type 2 papillary renal cell carcinoma

Classification / Lists

Renal epithelial neoplasms


  • Srigley JR, Delahunt B. Uncommon and recently described renal carcinomas. Mod Pathol. 2009 Jun;22 Suppl 2:S2-S23.
  • Lefèvre M, Couturier J, Sibony M, Bazille C, Boyer K, Callard P, Vieillefond A, Allory Y. Adult papillary renal tumor with oncocytic cells: clinicopathologic, immunohistochemical, and cytogenetic features of 10 cases. Am J Surg Pathol. 2005 Dec;29(12):1576-81.
  • Okada A, Sasaki S, Fujiyoshi Y, Niimi K, Kurokawa S, Umemoto Y, Kohri K. A case of oncocytic papillary renal cell carcinoma. Int J Urol. 2009 Sep;16(9):765-7.
  • Park BH, Ro JY, Park WS, Jee KJ, Kim K, Gong G, Cho YM. Oncocytic papillary renal cell carcinoma with inverted nuclear pattern: distinct subtype with an indolent clinical course. Pathol Int. 2009 Mar;59(3):137-46.
  • Masuzawa N, Kishimoto M, Nishimura A, Shichiri Y, Yanagisawa A. Oncocytic renal cell carcinoma having papillotubular growth: rare morphological variant of papillary renal cell carcinoma. Pathol Int. 2008 May;58(5):300-5.
  • Mai KT, Kohler DM, Robertson SJ, Belanger EC, Marginean EC. Oncocytic papillary renal cell carcinoma with solid architecture: mimic of renal oncocytoma. Pathol Int. 2008 Mar;58(3):164-8.
  • Kunju LP, Wojno K, Wolf JS Jr, Cheng L, Shah RB. Papillary renal cell carcinoma with oncocytic cells and nonoverlapping low grade nuclei: expanding the morphologic spectrum with emphasis on clinicopathologic, immunohistochemical and molecular features. Hum Pathol. 2008 Jan;39(1):96-101.
  • Hes O, Brunelli M, Michal M, Cossu Rocca P, Hora M, Chilosi M, Mina M, Boudova L, Menestrina F, Martignoni G. Oncocytic papillary renal cell carcinoma: a clinicopathologic, immunohistochemical, ultrastructural, and interphase cytogenetic study of 12 cases. Ann Diagn Pathol. 2006 Jun;10(3):133-9.
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