Oncocytic Papillary Renal Cell Carcinoma
Differential Diagnosis
| Renal Oncocytoma |
Oncocytic Papillary Renal Cell Carcinoma |
| Solid, with minimal, poorly developed papillary change |
Usually predominantly papillary |
| At most, rare, focal foamy macrophages |
May have clusters of foamy macrophages |
| Necrosis is rare and only microscopic foci |
May have tumor cell necrosis |
| AMACR/racemase/P504S usually negative |
AMACR/racemase/P504S positive |
Occasional oncocytic papillary renal cell carcinomas may be largely solid; the bottom three criteria are more important in such cases
The distinction might be significant since oncocytic papillary carcinomas may have a better prognosis, but more data is needed.
