Surgical Pathology Criteria

Multilocular Cystic Renal Cell Carcinoma

Differential Diagnosis

Conventional Clear Cell Renal Cell Carcinoma Multilocular Cystic Renal Cell Carcinoma
Both cystic and solid areas No solid areas
Nodules of clear cells are expansile and/or invasive Nests of clear cells are not expansile or invasive
May be low or high grade Must be low grade (1 or 2)

Multilocular Cystic Renal Cell Carcinoma Cystic Nephroma
3:1 M:F Nearly all female
Nests of clear cells in stroma No nests of clear cells in stroma
Lacks cellular ovarian type stroma Ovarian type stroma

Tubulocystic Carcinoma of the Kidney Multilocular Cystic Renal Cell Carcinoma
Lining cells have abundant eosinophilic cytoplasm Clear cells line cysts
No nests of clear cells Nests of clear cells in stroma
High grade nuclear features Low grade nuclear features

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