Surgical Pathology Criteria

Chromophobe Renal Cell Carcinoma

Supplemental Studies

Immunohistology

CD117 >90%, membranous
CK7 >70%
EMA >90
CD10 0 to focal
High molecular weight keratin 0
CAIX 0
PAX8 >80
CK7 typically diffuse in classic chromophobe carcinoma, but may be patchy, focal or even negative in eosinophilic variant
Also see markers in table below

Immunohistologic markers useful for distinguishing major types of renal cell carcinoma
  CA-IX Vim CD117 AMACR Racemase PN15 /PNRA/ gp200 CK7
Clear Cell 100% >85% <5% 15-25% 85% neg or focal
Papillary 50 >90 <20 >80 >85 20-80%
Chromophobe 0 0 >90 <15 0-45 >70% strong
Oncocytoma 0 0 >90 <15 0 neg to scattered
CA-IX = Carbonic Anhydrase IX; Vim = Vimentin; Clone PN15 anti-gp200 is sold as Renal Cell Carcinoma Marker, a unfortunately chosen, non-specific name

References for general IPOX of major types of RCC

Genetic Study

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