Surgical Pathology Criteria

Chromophobe Renal Cell Carcinoma

Differential Diagnosis

Conventional Clear Cell Renal Cell Carcinoma Chromophobe Renal Cell Carcinoma
Sheets and nests of clear cells with prominent surrounding vascular network Rigid cell membranes, central nuclei with surrounding nuclear clearing
CD117/KIT neg CD117/KIT pos
Vimentin, Carbonic Anhydrase IX generally pos Vimentin, Carbonic Anhydrase IX negative
Hale colloidal iron negative Hale colloidal iron positive

Chromophobe Renal Cell Carcinoma Renal Oncocytoma
Diffuse, sheet like pattern Nests floating in hypocellular stroma
Perinuclear halos usually prominent No perinuclear clearing
Clear cells usually prominent, frequently peripheral in nests Clear cells only focally in hyalinized scars
CK7 usually diffuse, strong CK7 usually negative or scattered positive cells
Hale colloidal iron stain diffusely positive Hale colloidal iron stain may be apical, but not diffuse, confluent

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