Clear cells usually prominent, frequently peripheral in nests
Clear cells only focally in hyalinized scars
CK7 usually diffuse, strong
CK7 usually negative or scattered positive cells
Hale colloidal iron stain diffusely positive
Hale colloidal iron stain may be apical, but not diffuse, confluent
This is one of the most problematic distinctions between renal neoplasms and may frequently be impossible
We consider a diagnosis of “oncocytic renal neoplasm” with a comment that chromophobe carcinoma cannot be completely excluded to be preferable to overdiagnosing a likely benign neoplasm as chromophobe carcinoma
