Fuhrman Grading Scheme (classical version)

  Nuclear Size Nuclear Shape Nucleoli
Grade 1 10 μ Round, uniform None
Grade 2 15 μ Irregular membrane at 400X Visible only at 400X
Grade 3 20 μ Obvious membrane irregularities Prominent, visible at 100X

Grade 4 carcinomas have bizarre, frequently multilobated nuclei with heavily clumped chromatin, may be sarcomatoid

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