"Sheets of B cells" is a term that describes a useful finding in the diagnosis of small B cell lymphomas.

• Benign lymphoid infiltrates are generally composed of either a dominant T cell population or a mixed population with compartmentalization of B and T cells
  • In such cases, B and T cell stains will either show few B cells or clear grouping of B cells into nodules with surrounding and infiltrating T cells
• If B cell stain shows a uniform sheet of B cells, this is strongly suggestive of lymphoma
  • We do not consider this to be sufficient for diagnosis of lymphoma
    • It can suggest further stains, genetic analysis or close clinical followup
  • Large numbers of T cells may also be present
    • If scattered uniformly throughout the B cell infiltrate they do not detract from the diagnosis

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