Surgical Pathology Criteria

Sinus Histiocytosis with Massive Lymphadenopathy

Differential Diagnosis


Reactive sinus hyperplasia


Langerhans cell histiocytosis is composed of S100 positive histiocytes that may have a sinusoidal distribution
Langerhans Cell Histiocytosis Sinus Histiocytosis with Massive Lymphadenopathy
Small to medium sized nuclei Large nuclei
Grooved, folded nuclei Round, vesicular nuclei
Inconspicuous nucleoli Prominent nucleoli
CD1a positive CD1a negative
No emperipolesis Prominent emperipolesis
Eosinophils frequent Eosinophils not frequent
Capsular fibrosis infrequent Capsular fibrosis frequent
Plasmacytosis infrequent Plasmacytosis frequent
Both are S100 positive.


Hemophagocytic lymphohistiocytosis


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