Surgical Pathology Criteria

Adenoma and Adenocarcinoma of the Small Intestine

Supplemental Studies

Immunohistology

  Small Intestine Adenocarcinoma Small Intestine Normal Mucosa
MUC1 52-82% Negative vs basal staining
MUC5AC 28-54% Negative, but goblets and gastric metaplasia positive

 

  Small Intestine Adenocarcinoma Colorectal Adenocarcinoma
Racemase 5% 62%
CK7 100% 5-10%
CK20 67% 95%
Small intestinal mucin antigen (SIMA) 50% 94%
Villin 67% 98%
CDX2 60% 70-98%

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