Surgical Pathology Criteria

Mucosal Schwann Cell Hamartoma

Differential Diagnosis

Mucosal Benign Epithelioid Nerve Sheath Tumor Mucosal Schwann Cell Hamartoma GI Ganglioneuroma
Epithelioid Spindled Spindled
No axons Very rare axons Axons present
No ganglion cells No ganglion cells Ganglion cells present
It is possible that Mucosal Benign Epithelioid Nerve Sheath Tumor and Mucosal Schwann Cell Hamartoma are related

GI Schwannoma GI Mucosal Schwann Cell Hamartoma
Most cases intramural Confined to lamina propria
Peripheral lymphoid cuff common Lacks lymphoid cuff
Frequent pleomorphic hyperchromatic cells No pleomorphism
90% in stomach Restricted to colorectum

GI Mucosal Schwann Cell Hamartoma GI Neurofibroma
Axons very rare to absent Axons scattered throughout
Very uniform infiltrate More heterogeneity in infiltrate
Restricted to colorectum Most are in stomach and small intestine

GI Mucosal Schwann Cell Hamartoma GI Perineurioma
Abundant cytoplasm Scant cytoplasm
No association with hyperplastic crypts Frequently associated with hyperplastic crypts
Perineurial markers negative Perineurial markers positive
S100 positive S100 negative

GI Mucosal Schwann Cell Hamartoma GI Mucosal Neuroma
Axons very rare to absent Axons numerous
Very uniform infiltrate Hyperplastic bundles of nerve fibers
Restricted to colorectum Very rare in intestines
No association with syndromes Associated with MEN2b

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