Gastrointestinal Lipid Island / Xanthoma
Supplemental Studies
- Histochemical stains of foam cells
- PAS negative
- Sudan Red positive (unprocessed tissue)
- Immunohistologic stains of foam cells
- Oxidized LDL positive (one case)
- Some histiocytic markers positive
- KP1, KiM1p, cathepsin D 100%
- Others weak to negative
- MAC387, lysozyme, alpha 1 antitrypsin
- Keratin negative
- Electron microscopy demonstrates lipid
- Predominantly in histiocytes
- Also in most other cells present including smooth muscle and plasma cells
