Inflammatory Fibroid Polyp
Supplemental Studies
Immunohistology
| CD34 |
80-90% |
| Fascin |
100% |
| CD35 |
100% (10% of cells) |
| Cyclin D1 |
100% |
| Calponin |
88% |
| Smooth muscle actin |
25% |
| CD117 (CKIT) |
0% |
| DOG1 |
0% |
| S100 |
0% |
| EMA, Keratin, Desmin, bcl2 |
0% |
- It has been proposed that IFPs that do not demonstrate a whorled concentric pattern make up the CD34 negative pattern (Kim 2000)
- This would suggest that IFP is made up of more than one process
- Expression of fascin and CD35 has been presented as evidence of dendritic cell origin (Pantanowitz 2004)
Genetic Studies
- Activating mutations in PDGFRA identified in 70% of cases
- Mutations identical to those seen in GIST
- Suggests that IFP are neoplastic
