Surgical Pathology Criteria

Gastrointestinal Stromal Tumor (GIST)

Supplemental Studies

Immunohistology

DOG1 87-94% (see note)
CD117 (KIT) 74-95% (see note)
Heavy caldesmon 80%
CD34 60-70%
Smooth muscle actin 30-40%
S100 5%*
Desmin 1-2%
Keratin 1-2%
SDHB Most positive#
*S100 15-20% in small intestine GIST, more frequent in NF1 associated cases
#Loss of SDHB staining identifies a distinct subset of syndromic or pediatric GIST
In side by side comparison studies:
  CD117 DOG1
GIST 74% 87%
GIST with PDGFRA mutation 9% 79%
Leiomyosarcoma 0.9% 0.3%
Synovial Sarcoma 0% 2.5%
Other lesions in DDx 0.5% 0.25%
Other sarcomas 10% 0%
Melanoma 30% 3%
Seminoma 86% 0%
Other non-mesenchymal 16% 1%

Molecular Studies

Stanford Medicine Resources:

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