Gastrointestinal Stromal Tumor (GIST)
Multicentric Sporadic GIST
- Multicentric sporadic GIST (see left sidebar for detailed criteria for GIST)
- Somatic CKIT or PDGFRA in 80%
- May have different mutations in different tumors from same patient
- Not familial
- Mean age 60
- Males and females affected
- Usually gastric
- Multiple small tumors in stomach accompanying one large one
- Multiple sites not involved
- Aggressive behavior is unusual
- Rule out all other syndromes of multiple GIST
- References (see left side bar for general GIST bibliography)
- Haller F, Schulten HJ, Armbrust T, Langer C, Gunawan B, Füzesi L. Multicentric sporadic gastrointestinal stromal tumors (GISTs) of the stomach with distinct clonal origin: differential diagnosis to familial and syndromal GIST variants and peritoneal metastasis. Am J Surg Pathol. 2007 Jun;31(6):933-7.
