Surgical Pathology Criteria

Gastrointestinal Stromal Tumor (GIST)

Grading / Staging / Report

Grading

Risk for Metastasis/Progressive Disease
  Stomach Duodenum Jejunum & Ileum Rectum
≤5 mits/50 hpf        
≤2cm 0 none 0 none 0 none 0 none
>2cm ≤5cm very low low low low
>5cm ≤10cm low high moderate high
>10cm moderate high high high
>5 mits/50 hpf        
≤2cm few cases no cases few cases high
>2cm ≤5cm moderate high high high
>5cm ≤10cm high high high high
>10cm high high high high
Large intestine tumors are rare, risk appears similar to jejunum&ileum
Esophageal tumors are too rare to develop criteria
With wide field microscope view, count 25 fields with same cutoff of 5 as above
Based on Miettinen and Lasota 2006

 

Progressive Disease or Death Risk Groups
Group Approximate Progression Incidence
0 None 0
Very low <2%
Low <5%
Moderate 10-30%
High >50%


Staging

Report should include:

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