High Grade / Poorly Differentiated Neuroendocrine Carcinoma of the Gastrointestinal Tract
Clinical
- Most cases present with nodal or distant metastases
- Poor prognosis
- Carcinoid syndrome is rare even if the liver is involved by metastases
- It is not clear that large cell endocrine carcinoma presently behaves differently from small cell carcinoma and high grade adenocarcinoma with current therapy
