High Grade / Poorly Differentiated Neuroendocrine Carcinoma of the Gastrointestinal Tract

Classification / Lists

Well differentiated processes including carcinoids
- Esophagus
  - Very rare
- Stomach
  - Gastric neuroendocrine cell hyperplasia and dysplasia
  - Carcinoid
- Duodenum and proximal jejunum
  - Predominantly ampullary
    - Somatostatinoma
    - Gangliocytic paraganglioma
  - Duodenum NOS and proximal jejunum
    - Gastrin cell neoplasm see also Zollinger Ellison syndrome
- Ileum and distal jejunum and cecum
  - Carcinoid, predominantly enterochromaffin cell, serotonin producing
- Appendix
  - Carcinoid, predominantly enterochromaffin cell, serotonin producing
  - Goblet cell carcinoid
- Large intestine
  - Cecum (see Ileum)
    - Carcinoid, predominantly enterochromaffin cell, serotonin producing
  - Rectum and distal colon
    - Carcinoid, predominantly L cell, glucagon-like peptide and pancreatic peptide (PP) producing
- Anus
  - Very rare
Poorly differentiated neuroendocrine carcinoma, all sites
- Small cell
- Large cell