Adenocarcinoma of the Stomach
Clinical
- Hepatoid variant has very poor prognosis
- Hereditary diffuse gastric carcinoma
- Autosomal dominant, 70% penetrance
- Carcinomas present at mean age 38
- Diagnosis requires either
- 2 cases in 1st or 2nd degree relatives, with one case <50 years, OR
- 3 cases in 1st or 2nd degree relatives, any age
- Females also at risk for lobular carcinoma of breast
- Endoscopy may be too insensitive to be of value
