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  • Surgical Pathology Criteria

    Gastrointestinal Autonomic Nerve Tumor (GANT)


    • Gastrointestinal stromal tumor (GIST) with ultrastructural features of neural differentiation

    Alternate/Historical Names

    • Plexosarcoma

    Diagnostic Criteria

    • GANT is currently considered to fall within the spectrum of GIST
      • They may simply be diagnosed as GIST
      • See GIST for detailed criteria, grading, differential diagnoses and bibliography
    • Light microscopic features are identical to GIST
      • May be spindled or epithelioid
    • Ultrastructural study have claimed to show features of neural differentiation
      • Complex long thin interdigitating cell processes
      • Processes joined by rudimentary cell junctions
      • Neurosecretory granules
      • Synapse-like structures
    • Immunohistochemical features are essentially the same as GIST
      • Some reports have described chromogranin and synaptophysin staining
        • No such staining was identified in a more recent study (Lee 2001)
      • Neuron specific enolase is positive but is not considered a specific marker
      • 100% CD117 positive, 58% CD34 positive
      • S100 variably reported, mean 39%
    • Genetic study has revealed mutations in KIT gene
    • Clinical behavior is same as GIST
    • We do not make this diagnosis
    • Reference
      • Lee JR, Joshi V, Griffin JW Jr, Lasota J, Miettinen M. Gastrointestinal autonomic nerve tumor: immunohistochemical and molecular identity with gastrointestinal stromal tumor. Am J Surg Pathol. 2001 Aug;25(8):979-87

    Teri A Longacre MD
    Robert V Rouse MD
    Department of Pathology
    Stanford University School of Medicine
    Stanford CA 94305-5342

    Original posting :December 5, 2009

    Printed from Surgical Pathology Criteria: http://surgpathcriteria.stanford.edu/
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