Gangliocytic Paraganglioma
Supplemental Studies
Immunohistology
- Immunohistologic stains show variable evidence of endocrine, neural and nerve sheath differentiation
- Epithelioid cells
- Keratin variably positive
- Variably positive for synaptophysin, chromogranin, pancreatic polypeptide, somatostatin, calcitonin, glucagon and insulin
- Occasionally neurofilament positive
- Ganglion cells
- Neurofilament and synaptophysin positive
- Variably positive for pancreatic polypeptide, somatostatin, calcitonin
- Spindle cells
- S100, neurofilament positive
