Surgical Pathology Criteria

Esophageal Submucosal Gland Duct Adenoma

Differential Diagnosis

Esophageal Submucosal Gland Duct Adenoma Esophageal or EGJ Adenocarcinoma NOS
Cytologically bland Cytologically dysplastic
Two cell layers Varies from single to multiple cell layers
Outer layer has myoepithelial phenotype No myoepithelial component
Circumscribed Invasive

 

Esophageal Submucosal Gland Duct Adenoma Esophageal or EGJ Adenocarcinoma, Clear Cell / Pylorocardiac Type
Two cell layers Varies from single to multiple cell layers
Inner layer has intensely eosinophilic cytoplasm Clear cells line tubules and papillae
Outer layer has myoepithelial phenotype No myoepithelial component
Lacks tumor cell necrosis Frequent coagulative tumor cell necrosis
Circumscribed Invasive
Clear cell / pylorocardiac adenocarcinoma may have bland cytologic features leading to confusion with an adenoma on a biopsy

 

Esophageal Submucosal Gland Duct Adenoma Gastric Adenomatous Polyp, Pyloric Type
Mixed tubular and papillary pattern Tubular, no papillary component
Two cell layers One cell layer
Outer layer has myoepithelial phenotype No myoepithelial component
Inner layer has intensely eosinophilic cytoplasm Pale eosinophilic cytoplasm

 

Esophageal Submucosal Gland Duct Adenoma Esophageal or Gastric Adenomatous Polyp, Intestinal Type
Cytologically bland Cytologically dysplastic
Two cell layers One cell layer
Outer layer has myoepithelial phenotype No myoepithelial component

Stanford Medicine Resources:

Footer Links: