Esophageal Submucosal Gland Duct Adenoma
Differential Diagnosis
- Adenocarcinoma esophageal or EGJ, NOS
- Adenocarcinoma esophageal or EGJ, clear cell type
- Gastric adenomatous polyp, pyloric type
- Gastric adenomatous polyp, intestinal type
| Esophageal Submucosal Gland Duct Adenoma | Esophageal or EGJ Adenocarcinoma NOS |
| Cytologically bland | Cytologically dysplastic |
| Two cell layers | Varies from single to multiple cell layers |
| Outer layer has myoepithelial phenotype | No myoepithelial component |
| Circumscribed | Invasive |
| Esophageal Submucosal Gland Duct Adenoma | Esophageal or EGJ Adenocarcinoma, Clear Cell / Pylorocardiac Type |
| Two cell layers | Varies from single to multiple cell layers |
| Inner layer has intensely eosinophilic cytoplasm | Clear cells line tubules and papillae |
| Outer layer has myoepithelial phenotype | No myoepithelial component |
| Lacks tumor cell necrosis | Frequent coagulative tumor cell necrosis |
| Circumscribed | Invasive |
| Esophageal Submucosal Gland Duct Adenoma | Gastric Adenomatous Polyp, Pyloric Type |
| Mixed tubular and papillary pattern | Tubular, no papillary component |
| Two cell layers | One cell layer |
| Outer layer has myoepithelial phenotype | No myoepithelial component |
| Inner layer has intensely eosinophilic cytoplasm | Pale eosinophilic cytoplasm |
| Esophageal Submucosal Gland Duct Adenoma | Esophageal or Gastric Adenomatous Polyp, Intestinal Type |
| Cytologically bland | Cytologically dysplastic |
| Two cell layers | One cell layer |
| Outer layer has myoepithelial phenotype | No myoepithelial component |
