Gastrin Cell Neoplasm / Gastrinoma of the Duodenum
Differential Diagnosis
Determination of common sites of origin for metastatic well differentiated endocrine neoplasms
| |
TTF1 |
CDX2 |
PDX1 |
ISL1 |
PAX8 |
| Lung |
40-50% |
Negative |
Negative |
Negative |
Negative |
| Pancreas |
Negative |
0-18% |
28% |
68% |
50-67% |
| Stomach |
Negative |
0-17% |
60% |
Negative |
20% |
| Duodenum |
Negative |
0-17% |
60% |
Negative |
100% |
| Ileum |
Negative |
>90% |
Negative |
Negative |
Negative |
| Appendix |
Negative |
>90% |
55% |
Negative |
21% |
| Rectum |
Negative |
0-55% |
17% |
Negative |
85% |
Detection of specific islet hormones may be useful; PAX8 data has been questioned (see
Pancreas).
Determination of common sites of origin for metastatic well differentiated endocrine neoplasms-keratins
| |
CK7 |
CK20 |
| Lung |
Variable |
Negative |
| Pancreas |
Variable |
Variable |
| Stomach |
Variable |
Negative |
| Duodenum |
Negative |
Variable |
| Ileum |
Negative |
Variable |
| Appendix |
Negative |
Variable |
| Rectum |
Variable |
Variable |
CK7/20 staining is only helpful in instances of positivity where a negative result is expected
