Cronkhite-Canada Syndrome
Differential Diagnosis
- Juvenile polyposis
- Cowden disease
- Peutz Jeghers syndrome
- Hereditary mixed polyposis syndrome
- Gastric hyperplastic polyp
- Menetrier disease
Cronkhite-Canada Syndrome | Juvenile Polyposis |
Most colorectal polyps sessile | Most colorectal polyps polypoid |
Hair, nail, skin changes present | No associated ectodermal changes |
No dysplasia | Infrequent cases may have focal dysplasia |
Not familial | Autosomal dominant, 75% are new mutations without family history |
Cronkhite-Canada Syndrome | Cowden Disease |
Hair, nail, skin pigmentation changes present | Most have facial mucocutaneous lesions, see description |
No association with breast hamartomas or carcinomas | Frequent breast hamartomas and carcinomas |
No association with thyroid carcinomas | Frequent thyroid carcinomas |
PTEN mutations not seen | PTEN mutations in 80% |
Not familial | Autosomal dominant (half are new mutations without family history) |
Cronkhite-Canada Syndrome | Peutz-Jeghers Syndrome |
May have facial pigmented macules but no mucosal involvement described | Mucocutaneous hyperpigmentation |
Hair, nail, skin pigmentation changes present | Internal neoplasms and non-GI polyps may occur |
Smooth muscle absent or only small amounts in lamina propria | Prominent arborizing smooth muscle bundles in GI polyps |
Frequent mucous retention cysts | Lacks retention cysts |
Lacks pseudoinvasion | May have displaced mucosa with pseudoinvasion of underlying muscularis propria |
Not familial | Autosomal dominant |
Cronkhite-Canada Syndrome | Hereditary Mixed Polyposis Syndrome |
Usually >50 polyps | Usually 1-15 polyps, rarely >50 |
Adenomas infrequent (sporadic adenomas may occur) | Adenomas common |
Hair, nail, skin pigmentation changes present | No associated extra-GI lesions |
Not familial | Autosomal dominant |
Cronkhite-Canada Syndrome, Gastric Involvement | Hyperplastic Polyps of the Stomach |
Usually >50 polyps | Usually solitary |
Hair, nail, skin pigmentation changes present | No associated extra-GI lesions |
Colorectal polyps very common | Not associated with colorectal polyps |
Cronkhite-Canada Syndrome, Gastric Involvement | Menetrier Disease |
Hair, nail, skin pigmentation changes present | No associated extra-GI lesions |
Colorectal polyps very common | Not associated with colorectal polyps |