Surgical Pathology Criteria

Squamous Carcinoma of the Colon and Rectum

Differential Diagnosis

  Colorectal Squamous Carcinoma Colorectal Adenosquamous Carcinoma Colorectal Adenocarcinoma with Squamous Metaplasia
Squamous component Malignant Malignant Benign
Glandular component Absent Malignant Malignant
Both components must be more than focal
Squamous Carcinoma of the Anus Colorectal Squamous Carcinoma
Must involve anal canal Must not involve the anal squamous mucosa
Some require that colorectal SCC be at least 5-7 cm from the anus

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