Surgical Pathology Criteria–

Signet Ring Adenocarcinoma of the Colon and Rectum

Differential Diagnosis

Carcinoma ex Goblet Cell Carcinoid, Signet Ring Cell Type Colorectal Signet Ring Adenocarcinoma
At least focal presence of typical GCC Lacks typical GCC component
No surface adenoma or in situ lesion May have surface adenoma or in situ component
Essentially always originates in appendix Arises in colorectum
Neuroendocrine stains are not useful for this differential as positive cells are usually infrequent in goblet cell carcinoid and may be seen in nonendocrine carcinomas.

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