Surgical Pathology Criteria

Mucinous Adenocarcinoma of the Colon and Rectum

Differential Diagnosis

Benign Extravasation of Mucin Colorectal Mucinous Adenocarcinoma
Usually associated with a benign lesion Usually has at least areas of usual adenocarcinoma
Usually very few epithelial cells in the pools Usually areas with increased cellularity within the pools
Epithelium usually limited to the point of rupture Usually epithelium is too widespread to be explained by rupture
Epithelial cells present do not show clear evidence of malignancy Epithelial cells may show marked cytologic atypia or cribriform architecture
Usually focal and superficial Usually aggressively dissecting into bowel wall
Frequently associated with inflammation and hemorrhage Usually no inflammation or hemorrhage
The presence of a mucin pool at the base of a GI epithelial neoplasm should prompt a careful examination for mucinous carcinoma

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