Goblet Cell Carcinoid of the Appendix
Grading / Staging / Report
- Pure goblet cell carcinoid (GCC) is by definition low grade
- Tang 2008 has proposed separating the following based on the histopathologic findings in the primary tumor (see Diagnostic Criteria at left):
- Goblet cell carcinoid, typical / pure
- Carcinoma ex GCC, signet ring type
- Carcinoma ex GCC, poorly differentiated type
- TNM 7th edition staging should follow that of non-carcinoid appendiceal adenocarcinomas
- Findings relevant to extent of disease should be included in the report
- Involvement of mesoappendix
- Involvement of surgical margin
- Involvement of lymph nodes
- Involvement of other organs or tissues
| Type | Stage I | Stage IIA | Stage IIIB | Stage IV |
| GCC, pure | 1%* |
60% 5 yr DSS 100% |
3%* 5 yr DSS 100% |
33% 5 yr DSS 100% |
| Ca ex-GCC, signet ring cell type | 0% | 4%* 5 yr DSS 100% |
8%* 5 yr DSS 100% |
88% 5 yr DSS 38% |
| Ca ex-GCC, poorly diff. | 0% | 0% | 0% | 100% 5 yr DSS 0% |
Entries marked with * represent only 1 or 2 cases
Stage IIA represents invasion of muscularis propria without node involvement
Stage IIIB represents node involvement without metastasis
Based on Tang 2008
