Surgical Pathology Criteria

Carcinoma Ex-goblet Cell Carcinoid of the Appendix

Supplemental Studies

Immunohistology

Marker Pure GCC Areas Signet Ring Type of Ca ex-GCC Poorly Differentiated Type of Ca ex-GCC
Synaptophysin 100% of cases, rare to 25% of cells May be negative or same as GCC May be negative or same as GCC
Chromogranin 100% of cases, rare to 25% of cells May be negative or same as GCC May be negative or same as GCC
CDX2 no data no data no data
CK7 Variable no data no data
CK20 100% no data no data
p53 Negative Positive Positive
MUC1 Negative Positive Positive
MUC2 Positive Negative Negative
Other neuroendocrine markers have been reported positive also
Neuroendocrine cells are positive with both argentaffin and argyrophil stains
Immunohistochemistry is not particularly useful for these distinctionsn

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