Carcinoma Ex-goblet Cell Carcinoid of the Appendix
Grading / Staging / Report
- Pure goblet cell carcinoid (GCC) is by definition low grade
- Tang 2008 has proposed separating the following based on the histopathologic findings in the primary tumor (see Diagnostic Criteria at left):
- Goblet cell carcinoid, typical / pure
- Carcinoma ex GCC, signet ring type
- Carcinoma ex GCC, poorly differentiated type
- TNM 7th edition staging should follow that of non-carcinoid appendiceal adenocarcinomas
- Findings relevant to extent of disease should be included in the report
- Involvement of mesoappendix
- Involvement of surgical margin
- Involvement of lymph nodes
- Involvement of other organs or tissues
DSS = Disease Specific SurvivalType Stage I Stage IIA Stage IIIB Stage IV GCC, pure 1%*
5 yr DSS 100%60%
5 yr DSS 100%3%*
5 yr DSS 100%33%
5 yr DSS 100%Ca ex-GCC, signet ring cell type 0% 4%*
5 yr DSS 100%8%*
5 yr DSS 100%88%
5 yr DSS 38%Ca ex-GCC, poorly diff. 0% 0% 0% 100%
5 yr DSS 0%
Entries marked with * represent only 1 or 2 cases
Stage IIA represents invasion of muscularis propria without node involvement
Stage IIIB represents node involvement without metastasis
Based on Tang 2008
