Appendiceal Carcinoid / Well Differentiated Endocrine Neoplasm
Grading / Staging
- Histopathologic features are predictive of behavior (based on WHO, Odze and AFIP, each are a bit different)
- Benign
- Non-functioning
- Well differentiated
- ≤2 cm in greatest dimension
- Confined to appendiceal wall
- No involvement of mesoappendix
- No vascular invasion
- Uncertain malignant behavior
- As for benign, but with:
- >2 cm in greatest dimension and/or
- Vascular invasion
- Low grade malignant
- Non-functioning and well differentiated, with:
- Invasion of mesoappendix and/or
- Metastasis
- OR, functioning and well differentiated
- Poorly differentiated endocrine carcinoma is covered separately
- Staging
- AJCC TNM 7th edition now includes carcinoids of the appendix
