Squamous Carcinoma of the Anus
Supplemental Studies
Immunohistology
- Usually positive:
- p63
- High molecular weight keratins (CK5/6, 34BE12)
- AE1 (CK 10,14 15, 16, 19)
- Variable reports for CK7
- Usually negative markers
- CAM5.2 (CK 8, 18) (one report)
- CK20
Genetic analysis
- High risk human papilloma virus (HPV) can be demonstrated in >90% of cases
