Dysplasia of the Anus
Grading / Staging / Report
Grading
| Low grade squamous intra-epithelial lesion (LSIL) | High grade squamous intra-epithelial lesion (HSIL) |
| Low nucleus/cytoplasmic (NC) ratio | NC ratio ≥ 1 |
| Orderly maturation | Disorderly maturation |
| Atypical cells confined to superficial layer | Atypical cells at all layers |
| Mitotic figures confined to basal layers unless inflamed | Mitotic figures at all levels |
| No atypical mitotic figures | Atypical mitotic figures may be seen |
Staging
- HSIL is staged as Tis
Report
- Should offer alternative terminology for the level of dysplasia if required by the submitting physicians
- If the dysplasia is present within a condyloma acuminatum the diagnosis should reflect the level present, e.g.:
- Condyloma acuminatum (LSIL), or
- Condyloma acuminatum, no evidence of high grade dysplasia
