Surgical Pathology Criteria

Anus and Perianus: Condyloma Acuminatum

Differential Diagnosis

Condyloma Acuminatum Non-specific Squamous Hyperplasia
Koilocytes at least focally present No koilocytes
Prominent parakeratosis Parakeratosis unusual


Condyloma Acuminatum Fibroepithelial Polyp
Koilocytes at least focally present No Koilocytes
Prominent parakeratosis Parakeratosis unusual
Lacks central stromal component Central stromal component, frequently with atypical stromal cells


Verrucous Carcinoma of the Anus Condyloma Acuminatum
Usually large Usually small
Blunt destructive downward growth Superficial lesion, no destructive growth
May develop fistulas and sinuses Does not produce fistulas or sinuses



Differential diagnosis related to the presence of HSIL in a condyloma is covered under Anal Dysplasia

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