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  • Surgical Pathology Criteria

    Zollinger Ellison Syndrome


    • Gastrointestinal changes secondary to a gastrin producing neoplasm with resultant small intestinal ulceration

    Diagnostic Criteria

    • Changes are secondary to a gastrin secreting neoplasm
      • 50-70% are duodenal and remainder are pancreatic
        • Duodenal neoplasms may be very small (< 1 mm)
    • Hyperplasia of parietal cells
      • Symptoms primarily related to ulcers due to increased acid secretion
        • Ulcers throughout small intestine
          • Removal of gastric body may lead to long term resolution of symptoms even if gastrin producing neoplasm cannot be removed
    • Hyperplasia of endocrine cells in gastric body is uniformly seen
    • Foveolar layer normal

    Robert V Rouse MD
    Department of Pathology
    Stanford University School of Medicine
    Stanford CA 94305-5342

    Original posting :xxxxx


    Gastrointestinal Endocrine Cell Proliferations and Neoplasms


    • Riddell RH, Petras RE, Williams GT, Sobin LH. Tumors of the Intestines, Atlas of Tumor Pathology, AFIP Third Series, Fascicle 32, 2003.
    • Hamilton SR, Aaltonen LA eds. Pathology and genetics of tumours of the digestive system. World Health Organization classification of tumours, Vol. 2. Lyon: IARC Press 2000.
    Printed from Surgical Pathology Criteria: http://surgpathcriteria.stanford.edu/
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