A wide variety of drugs have been implicated as causes, including NSADs (reviewed in Mahajan 2012)
Up to 15% of cases are found to be associated with (or a manifestation of ) celiac disease
Lymphocytic colitis may be the initial presentation
Age range 2-98 years
Mean age 50’s
Uncommon in children
Treatment may include drugs ranging from loperamide to budesonide or other steroids, depending upon the severity of disease (reviewed in Yen 2011, Mahajan 2012)
Relapses are frequent
Noffsinger A, Fenoglio-Preiser CM, Maru D, Gilinisky N. Gastrointestinal Diseases, AFIP Atlas of Nontumor Pathology, First Series, Fascicle 5, 2007.
Lazenby AJ. Collagenous and lymphocytic colitis. Semin Diagn Pathol. 2005 Nov;22(4):295-300.
Chang F, Deere H, Vu C. Atypical forms of microscopic colitis: morphological features and review of the literature. Adv Anat Pathol. 2005 Jul; 12(4):203-11.
Rubio CA, Lindholm J. Cryptal lymphocytic coloproctitis: a new phenotype of lymphocytic colitis? J Clin Pathol. 2002 Feb;55(2):138-40.
Goldstein NS, Bhanot P. Paucicellular and asymptomatic lymphocytic colitis: expanding the clinicopathologic spectrum of lymphocytic colitis. Am J Clin Pathol. 2004 Sep;122(3):405-11.
Ayata G, Ithamukkala S, Sapp H, Shaz BH, Brien TP, Wang HH, Antonioli DA, Farraye FA, Odze RD. Prevalence and significance of inflammatory bowel disease-like morphologic features in collagenous and lymphocytic colitis. Am J Surg Pathol. 2002 Nov;26(11):1414-23.
Fernández-Bañares F, Casalots J, Salas A, Esteve M, Rosinach M, Forné M, Loras C, Santaolalla R, Espinós J, Viver JM. Paucicellular lymphocytic colitis: is it a minor form of lymphocytic colitis? A clinical pathological and immunological study. Am J Gastroenterol. 2009 May;104(5):1189-98.
Padmanabhan V, Callas PW, Li SC, Trainer TD. Histopathological features of the
ileum in lymphocytic and collagenous colitis: a study of 32 cases and review of literature. Mod Pathol. 2003 Feb;16(2):115-9.
Sapp H, Ithamukkala S, Brien TP, Ayata G, Shaz B, Dorfman DM, Wang HH, Antonioli DA, Farraye FA, Odze RD. The terminal ileum is affected in patients with lymphocytic or collagenous colitis. Am J Surg Pathol. 2002 Nov;26(11):1484-92.
Yen EF, Pardi DS. Review of the microscopic colitides. Curr Gastroenterol Rep. 2011 Oct;13(5):458-64.
Kao KT, Pedraza BA, McClune AC, Rios DA, Mao YQ, Zuch RH, Kanter MH, Wirio S, Conteas CN. Microscopic colitis: a large retrospective analysis from a health maintenance organization experience. World J Gastroenterol. 2009 Jul 7;15(25):3122-7.
Mahajan D, Goldblum JR, Xiao SY, Shen B, Liu X. Lymphocytic colitis and collagenous colitis: a review of clinicopathologic features and immunologic abnormalities. Adv Anat Pathol. 2012 Jan;19(1):28-38.