Surgical Pathology Criteria

Lymphocytic Colitis

Differential Diagnosis


Incidental Chronic Colitis Lymphocytic Colitis
Crypt distortion and dropout No significant crypt distortion
Basal plasmacytosis Increase in lamina propria lymphocytes and plasma cells with intraepithelial lymphocytes
Isolated disease Usually multifocal
Virtually restricted to cecum/right colon May involve entire GI tract
Incidental, asymptomatic Intractable watery diarrhea in most cases

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