Drug related gastroenteritis must be ruled out clinically
Requires >1500 eosinophils / microliter
Parasitic disease must be ruled out by stool examination
May contain many eosinophils in the infiltrate but they do not predominate
Milk protein enteropathy must be ruled out clinically, especially in infants
Churg Strauss vasculitis
Graft versus host disease
Inflammatory fibroid polyp
Isolated polypoid lesion
May occur at any age
Peripheral eosinophilia in 40-50% of cases, but usually <1500/ml
Vomiting and diarrhea
Protein losing enteropathy
Associated with asthma, eczema, atopy
Noffsinger A, Fenoglio-Preiser CM, Maru D, Gilinisky N. Gastrointestinal Diseases, AFIP Atlas of Nontumor Pathology, First Series, Fascicle 5, 2007.
Lee CM, Changchien CS, Chen PC, Lin DY, Sheen IS, Wang CS, Tai DI, Sheen-Chen SM, Chen WJ, Wu CS. Eosinophilic gastroenteritis: 10 years experience. Am J Gastroenterol. 1993 Jan;88(1):70-4.
Talley NJ, Shorter RG, Phillips SF, Zinsmeister AR. Eosinophilic gastroenteritis: a clinicopathological study of patients with disease of the mucosa, muscle layer, and subserosal tissues. Gut. 1990 Jan;31(1):54-8.
Mueller S. Classification of eosinophilic gastrointestinal diseases. Best Pract Res Clin Gastroenterol. 2008;22(3):425-40.