Variable reports of prognosis and response to therapy
High mortality rate due to malnutrition in one series reporting very thick deposition(Maguire)
17/19 responsive to immunomodulatory therapy or gluten free diet with only 1/19 mortality in another series including only mild thickening(Vakiani)
Maguire AA, Greenson JK, Lauwers GY, Ginsburg RE, Williams GT, Brown IS, Riddell RH, O donoghue D, Sheahan KD. Collagenous Sprue: A Clinicopathologic Study of 12 Cases. Am J Surg Pathol. 2009 ;33:1440–1449..
Vakiani E, Arguelles-Grande C, Mansukhani MM, Lewis SK, Rotterdam H, Green PH, Bhagat G. Collagenous sprue is not always associated with dismal outcomes: a clinicopathological study of 19 patients. Mod Pathol. 2010;23:12-26.
Gopal P, McKenna BJ. The collagenous gastroenteritides: similarities and differences. Arch Pathol Lab Med. 2010 Oct;134(10):1485-9.